Plasmodium, Trypanosoma y Salmonella: marcadores moleculares
Palabras clave:
Biomarcadores, Plasmodium, Trypanosoma, Salmonella, Resistencia a medicamentos, Malaria grave, Bloqueo de la transmisión, Glicobiología, Blancos terapéuticos, PatogenicidadSinopsis
Realizar este libro de revisión con temas de investigación actual, sin mostrar resultados, sino antecedentes del proceso investigativo, nos ha permitido contar de forma extensa los fundamentos teóricos de donde se genera la nueva investigación básica y la fundamentación para la investigación clínica. Este libro ha sido escrito por investigadores que han recopilado la información a través de sus carreras investigativas y que han visto cómo evoluciona el conocimiento gracias a la aplicación de la biología molecular como herramienta en el estudio de las enfermedades infecciosas.
Cada capítulo del libro contiene información completa del conocimiento, hasta el día de hoy, de cada uno de los tópicos tratados; el tema en común son los biomarcadores moleculares de tres agentes infecciosos de importancia médica: Plasmodium spp., Trypanosoma spp. y Salmonella spp., agentes causales de enfermedades infecciosas de alta prevalencia en el mundo; las complicaciones que de ellas se derivan, como la sepsis y la falla multiorgánica, son importantes causas de morbilidad y mortalidad en los individuos afectados.
Capítulos
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Prólogo
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Introducción
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Marcadores genéticos de resistencia a la cloroquina en Plasmodium vivax
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Biomarcadores en la malaria complicada
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Aspectos biológicos y moleculares para el bloqueo de la transmisión durante el ciclo esporogónico de los parásitos de la malaria
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Marcadores glicobiológicos en la clasificación de las cepas de Trypanosoma cruzi
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Señalización molecular de tripanosomátidosquinasas como potenciales blancos terapéuticos y su mecanismo
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Marcadores genéticos de patogenicidad en Salmonella enterica serovar Typhimurium
Descargas
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Cox-Singh J, Davis TM, Lee KS, Shamsul SS, Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening, (in engl), Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, vol. 46, pp.165-7, 2008.
White NJ, Plasmodium knowlesi: the fifth human malaria parasite, (in engl), Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, vol. 46, pp.172-3, 2008.
Deane LM, Deane MP, Ferreira Neto J, Studies on transmission of simian malaria and on a natural infection of man with Plasmodium simium in Brazil, (in engl), Bull World Health Organ. Vol.35, no.5, pp. 805-8, 1966.
De Arruda M1, Nardin EH, Nussenzweig RS, Cochrane AH, Sero-epidemiological studies of malaria in Indian tribes and monkeys of the Amazon Basin of Brazil, (in engl), Am J Trop Med Hyg, vol. 41, no.4, pp.379-85. Oct 1989.
Lalremruata A, Magris M, Vivas-Martínez S, Koehler M, Esen M, Kempaiah P, Jeyaraj S, Perkins DJ, Mordmüller B, Metzger WG, Natural infection of Plasmodium brasilianum in humans: Man and monkey share quartan malaria parasites in the Venezuelan Amazon, (in engl), EBioMedicine, vol. 29, no.2, pp.1186-92, Jul 2015.
Ta TH, Hisam S, Lanza M, Jiram AI, Ismail N, Rubio JM, First case of a naturally acquired human infection with Plasmodium cynomolgi, (in engl), Malar J., vol.24 no.13 pp.68, Feb 2014.
Brasil P, Zalis MG, de Pina-Costa A, Siqueira AM, Júnior CB, Silva S, Areas ALL, Pelajo-Machado M, de Alvarenga DAM, da Silva Santelli ACF, Albuquerque HG, Cravo P, Santos de Abreu FV, Peterka CL, Zanini GM, Suárez Mutis MC, Pissinatti A, Lourenço-de-Oliveira R, de Brito CFA, de Fátima Ferreira-da-Cruz M, Culleton R, Daniel-Ribeiro CT, Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigation, (in engl), Lancet Glob Health, vol.5, no.10, pp.1038-1046, Oct 2017.
Douglas NM, Anstey NM, Angus BJ, Nosten F, Artemisinin combination therapy for vivax malaria, (in engl), The Lancet infectious diseases, vol.10, pp.405-16, 2010.
Alves FP, Durlacher RR, Menezes MJ, Krieger H, et al.: High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations, (in engl), The American journal of tropical medicine and hygiene, vol.66, pp.641-8, 2002.
Bejon P, Warimwe G, Mackintosh CL, Mackinnon MJ, et al.: Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure, (in engl), Infection and immunity, vol.77, pp.1917-23, 2009.
Baird JK, Jones TR, Danudirgo EW, Annis BA, et al.: Age-dependent acquired protection against Plasmodium falciparum in people having two years exposure to hyperendemic malaria, (in engl), The American journal of tropical medicine and hygiene, vol.45, pp.65-76, 1991.
Rogier C, Trape JF: Study of premunition development in holo- and meso-endemic malaria areas in Dielmo and Ndiop (Senegal): preliminary results, 1990-1994, (in engl), Medecine tropicale: revue du Corps de sante colonial, vol.55, pp.71-6, 1991.
Bezerril-Andrade BB-N, Manoel: Biomarkers for susceptibility to infection and disease severity in human malaria, (in engl), Mem Inst Oswaldo Cruz, vol.106, Supl.1, pp.70-8, 2011.
Greenwood BM, Bojang K, Whitty CJ, Targett GA: Malaria, (in engl), Lancet, vol.365, pp.1487-98, 2005.
OMS: Severe falciparum malaria, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.94, Suppl. 1, pp.1-90, 2000.
Price RN, Douglas NM, Anstey NM: New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance, (in engl), Current opinion in infectious diseases, vol. 22, pp.430-5, 2009.
Alexandre MA, Ferreira CO, Siqueira AM, Magalhaes BL, Severe Plasmodium vivax malaria, Brazilian Amazon, (in engl), Emerging infectious diseases, vol.16, pp.1611-4, 2010.
Anstey NM, Russell B, Yeo TW, Price RN, The pathophysiology of vivax malaria, (in engl), Trends in parasitology, vol.25, pp.220-7, 2009.
Choi HJ, Lee SY, Yang H, Bang JK, Retinal haemorrhage in vivax malaria, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.98, pp.387-9, 2004.
Chung BH, Lee SW, Lee SE, Hwang TJ, Predictors of Plasmodium vivax malaria-induced nephropathy in young Korean men, (in engl), Nephron Clinical practice, vol.110, pp.172-7, 2008.
Kochar DK, Saxena V, Singh N, Kochar SK, Plasmodium vivax malaria, (in engl), Emerging infectious diseases, vol.11, pp.132-4, 2005.
Kute VB, Trivedi HL, Vanikar AV, Shah PR, Plasmodium vivax malaria-associated acute kidney injury, India, 2010-2011, (in engl), Emerging infectious diseases, vol.18, pp.842-5, 2012.
Patel MP, Kute VB, Gumber MR, Gera DN, Shah PR, Patel HV, Trivedi HL, Vanikar AV, An unusual case of Plasmodium vivax malaria monoinfection associated with crescentic glomerulonephritis: a need for vigilance, (in engl), Parasitol Res, Jan; vol.112, no.1, pp.427-30, Jan 2013.
Prakash J, Singh AK, Kumar NS, Saxena RK, Acute renal failure in Plasmodium vivax malaria, (in engl), The Journal of the Association of Physicians of India, vol.51, pp.265-7, 2003.
Singh H, Parakh A, Basu S, Rath B, Plasmodium vivax malaria: is it actually benign?, (in engl), Journal of infection and public health, vol.4, pp.91-5, 2011.
Tanwar GS, Khatri PC, Sengar GS, Kochar A, et al.: Clinical profiles of 13 children with Plasmodium vivax cerebral malaria, (in engl), Annals of tropical paediatrics 2011, 31:351-6
Rieckmann KH, Davis DR, Hutton DC, Plasmodium vivax resistance to chloroquine? , (in engl), Lancet, vol.2, pp.1183-4, 1989.
Nomura T, Carlton JM, Baird JK, del Portillo HA, et al.: Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria, (in engl), The Journal of infectious diseases 2001, 183:1653-61
Brega S, Meslin B, de Monbrison F, Severini C, Identification of the Plasmodium vivax mdr-like gene (pvmdr1) and analysis of single-nucleotide polymorphisms among isolates from different areas of endemicity, (in engl), The Journal of infectious diseases, vol.191, pp.272-7, 2005.
Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Menard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Menard D, A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, (in engl), Nature, vol.505 pp.50, 2014.
Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegardh N, Socheat D, White NJ, Artemisinin resistance in Plasmodium falciparum malaria, (in engl), N. Engl. J. Med, vol.361, no.5, pp.455–67, 2009.
Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Duong S, Nguon C, Chuor CM, Saunders D, Se Y, Lon C, Fukuda MM, Amenga-Etego L, Hodgson AV, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su XZ, Ringwald P, Ariey F, Dolecek C, Hien TT, Boni MF, Thai CQ, AmambuaNgwa A, Conway DJ, Djimde AA, Doumbo OK, Zongo I, Ouedraogo JB, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O’Brien J, Gamble C, Oyola SO, Rayner JC, Newbold CI, Berriman M, Spencer CC, McVean G, Day NP, White NJ, Bethell D, Dondorp AM, Plowe CV, Fairhurst RM, Kwiatkowski DP. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia, (in engl), Nat. Genet, vol.45, pp.648, 2013.
Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM, Fukuda MM, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Socheat D, Ariey F, Phyo AP, Starzengruber P, Fuehrer HP, Swoboda P, Stepniewska K, Flegg J, Arze C, Cerqueira GC, Silva JC, Ricklefs SM, Porcella SF, Stephens RM, Adams M, Kenefic LJ, Campino S, Auburn S, MacInnis B, Kwiatkowski DP, Su XZ, White NJ, Ringwald P, Plowe CV, Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia, (in engl), Proc. Natl. Acad. Sci. U. S. A, vol.110, no.1, pp.240–5, 2013.
Flannery EL, Wang T, Akbari A, Corey VC, Gunawan F, Bright AT, Abraham M, Sanchez JF1, Santolalla ML1, Baldeviano GC1, Edgel KA1, Rosales LA1, Lescano AG1, Bafna V, Vinetz JM, Winzeler EA, Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes, (in engl), ACS Infect Dis. Vol.14, no.1, pp.367-79, Aug 2015.
Carlton JM1, Volkman SK2, Uplekar S2, Hupalo DN2, Pereira Alves JM2, Cui L2, Donnelly M2, Roos DS2, Harb OS2, Acosta M2, Read A2, Ribolla PE2, Singh OP2, Valecha N2, Wassmer SC2, Ferreira M2, Escalante AA2.: Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research, (in engl), Am J Trop Med Hyg, vol.93 Suppl.3, pp.87-98, Sep 2015.
OMS: World Malaria Report, 2009.
Juan Ricardo Cubides, Paola Andrea Camargo-Ayala, Carlos Hernando Niño, Diego Garzón-Ospina, Anggie Ortega-Ortegón, Estefany Ospina-Cantillo, María Fernanda Orduz-Durán, Manuel Elkin Patarroyo and Manuel Alfonso Patarroyo, Simultaneous detection of Plasmodium vivax dhfr, dhps, mdr1 and crt-o resistance-associated mutations in the Colombian Amazonian region, (in engl), Malaria Journal, vol.17, pp.130, 2018.
OMS: World Malaria Report, 2017.
Kumar S, Bawa S, Gupta H: Biological activities of quinoline derivatives, (in engl), Mini reviews in medicinal chemistry, vol.9, pp.1648-54, 2009.
Foley M, Tilley L, Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents, (in engl), Pharmacology & therapeutics, vol.79, pp.55-87, 1998.
Ekland EH, Fidock DA, In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes, (in engl), International journal for parasitology, vol.38, pp.743-7, 2008.
Smalley ME: Plasmodium falciparum gametocytes, The effect of chloroquine on their development, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.71, pp.526-9, 1977.
Bunnag D, Harinasuta T, Pinichpongse S, Suntharasami P, Effect of primaquine on gametocytes of Plasmodium falciparum in Thailand, (in engl), Lancet, vol.2, pp.91, 1980
Khanna N: Antimicrobial Agents, (in engl), Antiprotozoal Drugs, 2007.
OMS: Guidelines for the treatment of malaria, (in engl), World Health Organization, Geneve 2006.
Burgess SJ, Kelly JX, Shomloo S, Wittlin S, Brun R, Liebmann K, Peyton DH, Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds, (in engl), J Med Chem, vol.53, no.17, pp.6477-89, 2010.
Wellems TE & Plowe CV, Chloroquine-resistance malaria, (in engl), J Infec Dis, vol.184, pp.770-6, 2001.
Gustafsson LL, Lindstrom B, Grahnen A, Alvan G, Chloroquine excretion following malaria prophylaxis, (in engl), British journal of clinical pharmacology, vol.24, pp.221-4, 1987.
Baird JK, Chloroquine resistance in Plasmodium vivax, (in engl), Antimicrobial agents and chemotherapy, vol.48, pp.4075-83, 2004.
Baird JK, Rieckmann KH, Can primaquine therapy for vivax malaria be improved?, (in engl), Trends in parasitology, vol.19, pp.115-20, 2003.
Maguire JD, Krisin, Marwoto H, Richie TL, Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia, (in engl), Clin Infect Dis., vol.15, no. 42(8), pp.1067-72, Apr 2006.
Korsinczky M, Fischer K, Chen N, Baker J, Sulfadoxine resistance in Plasmodium vivax is associated with a specific amino acid in dihydropteroate synthase at the putative sulfadoxine-binding site, (in engl), Antimicrobial agents and chemotherapy, vol.48, pp.2214-22, 2004.
Hawkins VN, Joshi H, Rungsihirunrat K, Na-Bangchang K, Antifolates can have a role in the treatment of Plasmodium vivax, (in engl), Trends in parasitology, vol.23, pp.213-22, 2007.
Imwong M, Pukrittayakamee S, Cheng Q, Moore C, et al.: Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand, (in engl), Antimicrobial agents and chemotherapy, vol.49, pp.4393-5, 2005.
Lu F, Lim CS, Nam DH, Kim K, et al.: Mutations in the antifolate-resistance-associated genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium vivax isolates from malaria-endemic countries, (in engl), The American journal of tropical medicine and hygiene, vol.83, pp.474-9, 2010.
Deng S, Ruan Y, Bai Y, Hu Y, Deng Z, He Y, Ruan R, Wu Y, Yang Z, Cui L: Genetic diversity of the Pvk12 gene in Plasmodium vivax from the China-Myanmar border area, (in engl), Malar Journal, vol. 15(1), pp.528-533, 2016
Goldberg DE, Slater AF, Cerami A, Henderson GB: Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle, (in engl), Proceedings of the National Academy of Sciences of the United States of America, vol. 87, pp.2931-5, 1990.
Francis SE, Gluzman IY, Oksman A, Knickerbocker A, et al.: Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase, (in engl), The EMBO journal, vol.13, pp.306-17, 1994.
Moura PA, Dame JB, Fidock DA: Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors, (in engl), Antimicrobial agents and chemotherapy, vol.53, pp.4968-78, 2009.
Salas F, Fichmann J, Lee GK, Scott MD, et al.: Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase, (in engl), Infection and immunity, vol.63, pp.2120-5, 1995.
Sherman IW, Jones LA: Plasmodium lophurae: membrane proteins of erythrocyte-free plasmodia and malaria-infected red cells, (in engl), The Journal of protozoology, vol.26, pp.489-501, 1979.
Homewood CA, Warhurst DC, Peters W, Baggaley VC: Lysosomes, pH and the anti-malarial action of chloroquine, (in engl), Nature, vol.235, pp.50-2, 1972.
Yayon A, Timberg R, Friedman S, Ginsburg H: Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite Plasmodium falciparum, (in engl), The Journal of protozoology, vol.31, pp.367-72, 1984.
Ferrari V, Cutler DJ: Kinetics and thermodynamics of chloroquine and hydroxychloroquine transport across the human erythrocyte membrane, (in engl), Biochemical pharmacology 1991, 41:23-30
Slater AF: Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum, (in engl), Pharmacology & therapeutics 1993, 57:203-35
Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs, (in engl), Life sciences 2004, 74:1957-72
Orjih AU, Ryerse JS, Fitch CD: Hemoglobin catabolism and the killing of intraerythrocytic Plasmodium falciparum by chloroquine, (in engl), Experientia 1994, 50:34-9
OMS: Global report on antimalarial efficacy and drug resistance: 2000-2010, 2010.
Price RN, S.; Marfurt, J.; Cheng, Q.: Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax, (in engl), Trends Parasitol 2012, Nov; 28: 522-9
Craig AA, Kain KC: Molecular analysis of strains of Plasmodium vivax from paired primary and relapse infections, (in engl), The Journal of infectious diseases 1996, 174:373-9
Kirchgatter K, del Portillo HA: Molecular analysis of Plasmodium vivax relapses using the MSP1 molecule as a genetic marker, (in engl), The Journal of infectious diseases 1998, 177:511-5
Bruce MC, Galinski MR, Barnwell JW, Snounou G, et al.: Polymorphism at the merozoite surface protein-3alpha locus of Plasmodium vivax: global and local diversity, (in engl), The American journal of tropical medicine and hygiene 1999, 61:518-25
Ferreira MU, Karunaweera ND, da Silva-Nunes M, da Silva NS, et al.: Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia, (in engl), The Journal of infectious diseases, vol.195, pp.1218-26, 2007.
Valderramos SG, Scanfeld D, Uhlemann AC, Fidock DA, et al.: Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance, (in engl), Antimicrobial agents and chemotherapy, vol.54, pp.3842-52, 2010.
Roper C, Pearce R, Nair S, Sharp B, et al.: Intercontinental spread of pyrimethamine-resistant malaria, (in engl), Science, vol.305, pp.1124, 2004.
Wootton JC, Feng X, Ferdig MT, Cooper RA, et al.: Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum, (in engl), Nature, vol.418, pp.320-3, 2002.
Wongsrichanalai C, Lin K, Pang LW, Faiz MA, et al.: In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs, (in engl), The American journal of tropical medicine and hygiene, vol.65, pp.450-5, 2001.
Vinayak S, Alam MT, Mixson-Hayden T, McCollum AM, et al.: Origin and evolution of sulfadoxine resistant Plasmodium falciparum, (in engl), PLoS pathogens 2010, 6:e1000830, 2010.
Korsinczky M, Chen N, Kotecka B, Saul A, et al.: Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site, (in engl), Antimicrobial agents and chemotherapy, vol.44, pp.2100-8, 2000.
Petersen I1, Eastman R, Lanzer M.: Drug-resistant malaria: molecular mechanisms and implications for public health, (in engl), FEBS Lett. Vol.6, no. 585(11), pp.1551-62, Jun 2011.
Baird JK, Basri H, Subianto B, Fryauff DJ, et al.: Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine, (in engl), The Journal of infectious diseases vol.171, pp.1678-82, 1995.
Pukrittayakamee S, Vanijanonta S, Chantra A, Clemens R, et al.: Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria, (in engl), The Journal of infectious diseases, vol.169, pp.932-5, 1994.
Suwanarusk R, Russell B, Chavchich M, Chalfein F, et al.: Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms, (in engl), PloS one vol.2, pp.1089, 2007.
Baird JK: Resistance to therapies for infection by Plasmodium vivax, (in engl), Clinical microbiology reviews, vol.22, pp.508-34, 2009.
Baird JK, Leksana B, Masbar S, Fryauff DJ, et al.: Diagnosis of resistance to chloroquine by Plasmodium vivax: timing of recurrence and whole blood chloroquine levels, (in engl), The American journal of tropical medicine and hygiene, vol.56, pp.621-6, 1997.
Ratcliff A, Siswantoro H, Kenangalem E, Wuwung M, et al.: Therapeutic response of multidrug-resistant Plasmodium falciparum and P.vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene vol.101, pp.351-9, 2007.
Sumawinata IW, Bernadeta, Leksana B, Sutamihardja A, et al.: Very high risk of therapeutic failure with chloroquine for uncomplicated Plasmodium falciparum and P. vivax malaria in Indonesian Papua, (in engl), The American journal of tropical medicine and hygiene, vol.68, pp.416-20, 2003.
Sutanto I, Suprijanto S, Nurhayati, Manoempil P, et al.: Resistance to chloroquine by Plasmodium vivax at Alor in the Lesser Sundas Archipelago in eastern Indonesia, (in engl), The American journal of tropical medicine and hygiene, vol.81, pp.338-42, 2009.
Murphy GS, Basri H, Purnomo, Andersen EM, et al.: Vivax malaria resistant to treatment and prophylaxis with chloroquine, (in engl), Lancet, vol.341, pp.96-100, 1993.
Karunaweera ND, Ferreira MU, Munasinghe A, Barnwell JW, et al.: Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax, (in engl), Gene, vol.410, pp.105-12, 2008.
Singh RK: Emergence of chloroquine-resistant vivax malaria in south Bihar (India), (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.94, pp.327, 2000.
Guthmann JP, Pittet A, Lesage A, Imwong M, et al.: Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar, (in engl), Tropical medicine & international health, vol.13, pp.91-8, 2008.
Kurcer MA, Simsek Z, Zeyrek FY, Atay S, et al.: Efficacy of chloroquine in the treatment of Plasmodium vivax malaria in Turkey, (in engl), Annals of tropical medicine and parasitology, vol.98, pp. 447-51, 2004.
Barnadas C, Ratsimbasoa A, Tichit M, Bouchier C, et al.: Plasmodium vivax resistance to chloroquine in Madagascar: clinical efficacy and polymorphisms in pvmdr1 and pvcrt-o genes, (in engl), Antimicrobial agents and chemotherapy, vol.52, pp.4233-40, 2008.
De Santana Filho FS, Arcanjo AR, Chehuan YM, Costa MR, et al.: Chloroquine-resistant Plasmodium vivax, Brazilian Amazon, (in engl), Emerging infectious diseases, vol.13, pp.1125-6, 2007.
Baird JK, Sustriayu Nalim MF, Basri H, Masbar S, et al.: Survey of resistance to chloroquine by Plasmodium vivax in Indonesia, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.90, pp.409-11, 1996.
Kolaczinski K, Durrani N, Rahim S, Rowland M: Sulfadoxine-pyrimethamine plus artesunate compared with chloroquine for the treatment of vivax malaria in areas co-endemic for Plasmodium falciparum and P.vivax: a randomised non-inferiority trial in eastern Afghanistan, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.101, pp.1081-7, 2007.
Lee KS, Kim TH, Kim ES, Lim HS, et al.: Short report: chloroquine-resistant Plasmodium vivax in the Republic of Korea, (in engl), The American journal of tropical medicine and hygiene, vol.80, pp.215-7, 2009.
Marlar T, Myat Phone K, Aye Yu S, Khaing Khaing G, et al.: Development of resistance to chloroquine by Plasmodium vivax in Myanmar, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.89, pp.307-8, 1995.
Phan GT, de Vries PJ, Tran BQ, Le HQ, et al.: Artemisinin or chloroquine for blood stage Plasmodium vivax malaria in Vietnam, (in engl), Tropical medicine & international health, vol.7, pp.858-64, 2002.
Srivastava HC, Yadav RS, Joshi H, Valecha N, et al.: Therapeutic responses of Plasmodium vivax and P. falciparum to chloroquine, in an area of western India where P. vivax predominates, (in engl), Annals of tropical medicine and parasitology, vol.102, pp.471-80, 2008.
Soto J, Toledo J, Gutierrez P, Luzz M, et al.: Plasmodium vivax clinically resistant to chloroquine in Colombia, (in engl), The American journal of tropical medicine and hygiene, vol.65, pp.90-3, 2001.
Summers RL, Martin RE: Functional characteristics of the malaria parasite’s “chloroquine resistance transporter”: implications for chemotherapy, (in engl), Virulence. vol.1, pp.304-8, 2010.
Su X, Kirkman LA, Fujioka H, Wellems TE: Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa, (in engl), Cell, vol.91, pp.593-603, 1997.
Wellems TE, Panton LJ, Gluzman IY, do Rosario VE, et al.: Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross, (in engl), Nature, vol.345, pp.253-5, 1990.
Wellems TE, Walker-Jonah A, Panton LJ: Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7, (in engl), Proceedings of the National Academy of Sciences of the United States of America, vol.88, pp.3382-6, 1991.
Fidock DA, Nomura T, Talley AK, Cooper RA, et al.: Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance, (in engl), Molecular cell, vol.6, pp.861-71, 2000.
Chen N, Kyle DE, Pasay C, Fowler EV, et al.: pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines, (in engl), Antimicrobial agents and chemotherapy, vol.47, pp.3500-5, 2003.
Martin RE, Kirk K: The malaria parasite’s chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily, (in engl), Molecular biology and evolution, vol.21, pp.1938-49, 2004.
Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, et al.: A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance, (in engl), The EMBO journal, vol.24, pp.2294-305, 2005.
Lehane AM, Hayward R, Saliba KJ, Kirk K: A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites, (in engl), Journal of cell science, vol.121, pp.1624-32, 2008.
Hayward R, Saliba KJ, Kirk K.: The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance, (in engl), J Cell Sci, vol.15, no.119 pp.1016-25, Mar 2006.
Klonis N, Tan O, Jackson K, Goldberg D, et al.: Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum, (in engl), The Biochemical journal vol.407, pp.343-54, 2007.
Kuhn Y1, Rohrbach P, Lanzer M.: Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin, (in engl), Cell Microbiol, vol. 9, no.4, pp.1004-13, 2007.
Johnson DJ, Fidock DA, Mungthin M, Lakshmanan V, et al.: Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents, (in engl), Molecular cell, vol.15, pp.867-77, 2004.
Bray PG, Martin RE, Tilley L, Ward SA, et al.: Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance, (in engl), Molecular microbiology, vol.56, pp.323-33, 2005.
Bray PG, Mungthin M, Hastings IM, Biagini GA, et al.: PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX, Molecular microbiology, vol.62, pp.238-51, 2006.
Warhurst DC, Craig JC, Adagu IS: Lysosomes and drug resistance in malaria, (in engl), Lancet vol.360, pp.1527-9, 2002.
Sanchez CP, Rohrbach P, McLean JE, Fidock DA, et al.: Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum, (in engl), Molecular microbiology, vol.64, pp.407-20, 2007.
Cui L, Escalante AA, Imwong M, Snounou G: The genetic diversity of Plasmodium vivax populations, Trends in parasitology, vol.19, pp.220-6, 2003.
Escalante AA, Cornejo OE, Rojas A, Udhayakumar V, et al.: Assessing the effect of natural selection in malaria parasites, (in engl), Trends in parasitology, vol.20, pp.388-95, 2004.
Brito CF, Ferreira MU: Molecular markers and genetic diversity of Plasmodium vivax, (in engl), Memorias do Instituto Oswaldo Cruz, vol.106, Suppl 1, pp.12-26, 2011.
Mu J, Ferdig MT, Feng X, Joy DA, et al.: Multiple transporters associated with malaria parasite responses to chloroquine and quinine, (in engl), Molecular microbiology, vol.49, pp.77-89, 2003.
Allen JD, Brinkhuis RF, van Deemter L, Wijnholds J, et al.: Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance, (in engl), Cancer research, vol.60, pp.5761-6, 2000.
Chakraborti PK, Bhatt K, Banerjee SK, Misra P: Role of an ABC importer in mycobacterial drug resistance, (in engl), Bioscience reports, vol.19, pp.293-300, 1999.
Ouellette M, Legare D, Papadopoulou B: Microbial multidrug-resistance ABC transporters, (in engl), Trends in microbiology, vol.2, pp.407-11, 1994.
Cojean S, Noel A, Garnier D, Hubert V, et al.: Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa, (in engl), Malaria journal, vol.5, pp.24, 2006.
Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, et al.: High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1, (in engl), The Journal of infectious diseases, vo.183, pp.1535-8, 2001.
Duraisingh MT, Cowman AF: Contribution of the pfmdr1 gene to antimalarial drug-resistance, (in engl), Acta tropica, vol.94, pp.181-90, 2005.
Reed MB, Saliba KJ, Caruana SR, Kirk K, et al.: Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum, (in engl), Nature, vol.403, no.906-9, 2000.
Sá JM, Yamamoto MM, Fernandez-Becerra C, de Azevedo MF, Papakrivos J, Naudé B, Wellems TE, Del Portillo HA.: Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum, (in engl), Mol Biochem Parasitol. Vol.150, no. (2, pp.219-28, Dec 2006.
Sa JM, Nomura T, Neves J, Baird JK, et al.: Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains, (in engl), Experimental parasitology, vol.109, pp.256-9, 2005.
Tjitra E, Anstey NM, Sugiarto P, Warikar N, Kenangalem E, Karyana M, Lampah DA, Price RN.: Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia, (in engl), PLoS Med., vol.17, no.5, pp.128, 2008.
Baird JK.: Neglect of Plasmodium vivax malaria, (in engl), Trends Parasitol, vol.23, no.11, pp.533-9, Nov 2007.
Lacerda MV, Alexandre MA, Santos PD, Arcanjo AR, Alecrim WD, Alecrim MG.: Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon, (in engl), Acta Trop. Vol.90, no.2, pp.187-90, Apr 2004.
Fernández-Becerra C, Pinazo MJ, González A, Alonso PL, et al., Increased expression levels of the pvcrt-o and pvmdr1 genes in a patient with severe Plasmodium vivax malaria, (in engl), Malar J. vol.2, pp.55, Apr 2009.
Orjuela-Sanchez P, de Santana Filho FS, Machado-Lima A, Chehuan YF, et al.: Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region, (in engl), Antimicrobial agents and chemotherapy, vol.53, pp.3561-4, 2009.
Picot S, Burnod J, Bracchi V, Chumpitazi BF, et al.: Apoptosis related to chloroquine sensitivity of the human malaria parasite Plasmodium falciparum, (in engl), Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.91, pp.590-1, 1997